| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Infectivity of GI and GII noroviruses established from oyster related outbreaks
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| Autores: |
Thebault, Anne
Teunis, Peter F. M.
Le Pendu, Jacques
Le Guyader, Soizick
Denis, Jean-baptiste
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| Data: |
2013-06
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| Ano: |
2013
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| Palavras-chave: |
Norovirus
Shellfish
Bayesian analysis
Dose-response relationship
Fucosyltransferases
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| Resumo: |
Noroviruses (NoVs) are the major cause of acute epidemic gastroenteritis in industrialized countries. Outbreak strains are predominantly genogroup II (GII) NoV, but genogroup I (GI) strains are regularly found in oyster related outbreaks. The prototype Norwalk virus (GI), has been shown to have high infectivity in a human challenge study. Whether other NoVs are equally infectious via natural exposure remains to be established. Human susceptibility to NoV is partly determined by the secretor status (Se+/-). Data from five published oyster related outbreaks were analyzed in a Bayesian framework. Infectivity estimates where high and consistent with NV(GI) infectivity, for both GII and GI strains. The median and CI95 probability of infection and illness, in Se+ subjects, associated with exposure to a mean of one single NoV genome copy were around 0.29[0.015-0.61] for GI and 0.4[0.04-0.61] for GII, and for illness 0.13[0.007-0.39] for GI and 0.18[0.017-0.42] for GII. Se-subjects were strongly protected against infection. The high infectivity estimates for Norwalk virus GI and GII, makes NoVs critical target for food safety regulations.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00148/25927/24030.pdf
DOI:10.1016/j.epidem.2012.12.004
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| Editor: |
Elsevier Science Bv
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| Relação: |
http://archimer.ifremer.fr/doc/00148/25927/
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| Formato: |
application/pdf
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| Fonte: |
Epidemics (1755-4365) (Elsevier Science Bv), 2013-06 , Vol. 5 , N. 2 , P. 98-110
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| Direitos: |
2013 Elsevier B.V. All rights reserved.
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